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Since moisture is one of the critical requirements for mold growth, and can be controlled, In order to be effective the humidity levels in the structure must be aggressively lowered and maintained.
In Northern climates the foundation can be considered the coldest surface during humid periods, because the ground temperature remains approximately 52F. In the South, portions of the air conditioning duct work probably represents the coldest points. The air in the structure must be dehumidified to a dew point (saturation temperature) lower than these. In order to be effective the humidity levels in the structure must be aggressively lowered and maintained. The necessary relative humidity level is determined by the coldest surface area in the structure.